5 = 100: Long Live the “Filologicheskaia Revoliutsiia”

How to Live 100 Years

It is universally agreed, that custom, in time, becomes a second nature, forcing men to use that, whether good or bad, to which they have been habituated; in fact, we see habit, in many instances, gain the ascendancy over reason. This is so undeniably true, that virtuous men, by keeping company with wicked, often fall into the same vicious course of life. Seeing and considering all this, I have...

Long live the pore

n the first in vivo characterization of nuclear pore complex (NPC) dynamics in mammalian cells, Daigle et al. (page 71; see also the Comment on page 17) have found that NPCs are remarkably stable complexes that appear to be anchored to a protein network in the nuclear envelope. The work also demonstrates the feasibility of tracking single protein complexes in living cells. By fusing GFP tags to...

The TPP Is Dead, Long Live the TPP? A Response to Recent Commentaries

Long live the unreasonable man.

541 SHAW’S FAMOUS REMARK encapsulates more dimensions of my attitude to the crusade against aging than may be initially apparent. Here I will elaborate on three. In an equally well-known remark, St. Francis of Assisi is reported to have said (albeit, presumably, in Latin): “Lord grant me the serenity to accept the things I cannot change, the courage to change the things I can, and the wisdom to...

Long live dynamic parameters!

In a recent article about pulse pressure variation (PPV), after 4 pages of physiologic explanations, Dr Sondergaard finally concluded that ‘the subject is an exceptional demonstration of physiology but hardly guides the management of critically ill patients’ [1]. If I agree with the first part of this statement (I and others spent years dissecting the complex physiology behind PPV), I strongly ...